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Picture Of Kristina Nilsson-Ekdahl

Kristina Nilsson-Ekdahl

Professor

EmploymentProfessor

School of Natural Sciences

Visit AddressNorra vägen 49,39234
Postal AddressNorrgård, SE-39182 Kalmar
Emailkristina.nilsson-ekdahl@hik.se
Office Phone0480-446269
Cell Phone072-2320726
Fax0480-446262

Subject List
SubjectSubject Area
ImmunologyBiomedical Sciences

Project List
TitleSubjectStartedEnded
Biocompatibility of Blood-Contacting Surfaces – Lessons LearImmunology20052010
Polymorphisms in innate immunity genesBiomedical Sciences20052010

Publication List

Journal paper (peer-reviewed)

Bäck, J., Sanchez, J., Elgue, G., Nilsson-Ekdahl, K. and Nilsson, B. (2010). Activated platelets induce FXII-mediated contact activation. Biochem Biophys Res Commun. 391. 11-17.
Nilsson, B., Korsgren, O., Lambris, J. and Nilsson-Ekdahl, K. (2010). Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition. Trends in Immunology. 31. 32-38.
Nilsson, P., Engberg, A., Bäck, J., Faxälv, L., Lindahl, T., Nilsson, B. and Nilsson-Ekdahl, K. (2010). Immobilization of apyrase creates and antithrombotic biomaterial surface. Biomaterials. in press.
Babiker, A.A., Magnusson, P.U., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2010). Pro- and Antiangiogenic Factors in Prostasomes of Normal and Malignant Cell Origin.. The Prostate. in press.
Mangsbo, S., Sanchez, J., Anger, K., Lambris, J., Loskog, A., Nilsson-Ekdahl, K., Nilsson, B. and Tötterman, T. (2009). Complement activation by CpG 2006 in a human whole blood loop system; potential mechanisms and ensuing immune related effects. Journal of Immunology. 183. 6724-6731.
Lundgren, B.A., Rorsman, F., Portela-Gomes, G., Grimelius, L., Nilsson-Ekdahl, K., Nilsson, B. and Ekwall, O. (2009). Identification of complement C3 as an autoantigen in inflammatory bowel disease. Journal of Gastroenterology and Hepatology. Oct 13. [Epub ahead of print].
Tsai, J.A., Lund, M., Lundell, L. and Nilsson-Ekdahl, K. (2009). One-lung ventilation during thoracoabdominal esophagectomy elicits complememnt activation. Journal of Surgical Research. 152. 331-337.
Bäck, J., Huber-Lang, M., Sanchez, J., Nilsson-Ekdahl, K. and Nilsson, B. (2009). Regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and artificial surfaces.. Biomaterials. 30. 6573-80.
Nilsson-Ekdahl, K., Blomberg, C., Henningsson Johnsson, A., Dahle, C., Håkansson, I., Sandholm, K. and Ernerudh, J. (2009). Systemic and Intrathecal Complement Activation in Multiple Sclerosis and Guillan-Barré Syndrome. Molecular Immunology. 46. 2848.
Hamad, O.A., Nilsson-Ekdahl, K., Nilsson, P., Andersson, J., Magotti, P., Lambris, J.D. and Nilsson, B. (2008). Complement activation triggered by chondroitin sulfate reelased by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis. 6. 1413-1421.
Goto, M., Tjernberg, J., Dufrane, D., Elgue, G., Brandhorst, D., Nilsson-Ekdahl, K., Brandhorst, H., Wennberg, L., Kurokawa, Y., Satomi, S., Gianello, P., Korsgren, O. and Nilsson, B. (2008). Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation. 15. 225-234.
Markiewski, M., Nilsson, B., Nilsson-Ekdahl, K., Mollnes, T.E. and Lambris, J.D. (2007). Complement and Coagulation: Strangers or Partners in Crime?. Trends in Immunology. 28(4). 184-192.
Nilsson-Ekdahl, K., Henningsson, A.J., Sandholm, K., Forsberg, P., Ernerudh, J. and Ekerfelt, C. (2007). Immunity in borreliosis with special emphasis on the role of complement. Advances in Experimental Medicine and Biology. 598. 198-213.
Babiker, A.A., Hamad, O.A., Sanchez, J., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2007). Prothrombotic Effect of Prostasomes of Metastatic Cell and Seminal Origin. The Prostate. 67. 378-388.
Babiker, A.A., Nilsson-Ekdahl, K., Nilsson, B. and Ronquist, G. (2007). Prothrombotic Effects of Prostasomes Isolated from Prostatic Cell Lines and Seminal Plasma. Seminars in Thrombosis and Hemostasis. 33. 80-86.
Henningsson, A.J., Ernerudh, J., Sandholm, K., Carlsson, S., Granlund, H., Jansson, C., Nyman, D., Forsberg, P. and Nilsson-Ekdahl, K. (2007). Raised Intrathecal Levels of Complement Components C1q and C3a in Acute Neuroborreliosis. J Neuroimmunol. 183(1-2). 200-207.
Norda, R., Knutson, F., Berseus, O., Åkerblom, O., Nilsson-Ekdahl, K., Stegmayr, B. and Nilsson, B. (2007). Unexpected effects of donor gender on the storage of liquid plasma. Vox sang. 93. 223-228.
Babiker, A.A., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2006). Overexpression of ecto-protein kinases in prostasomes of metastatic origin. Prostate. 66 (7). 675-686.
Nilsson-Ekdahl, K., Ronquist, G., Nilsson, B. and Babiker, A.A. (2006). Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: A new paradigm for prostatic cancer?. Advances in experimental medicine and biology. 586. 107-119.
Nilsson, B., Nilsson-Ekdahl, K., Mollnes, T.E. and Lambris, J.D. (2006). The role of complement in biomaterial-induced inflammation. Molecular immunology. 44 (1-3). 82-94.
Hong, J., Azens, A., Nilsson-Ekdahl, K., Granqvist, C.G. and Nilsson, B. (2005). Contact between various metal surfaces and whole blood causes material-specific thrombin generation. Biomaterials. 26 (12). 1397-1403.
Mathsson, L., Tejde, A., Carlson, K., Höglund, M., Nilsson, B., Nilsson-Ekdahl, K. and Rönnelid, J. (2005). Cryoglobulin-induced cytokine production via Fc-gamma-RIIa: inverse effects of complement blockade on the production of TNF-alfa and IL-10. Implications for the growth of malignant B-cell clones. British journal of haematology. 129 (6). 830-838.
Nilsson-Ekdahl, K., Ronquist, G., Nilsson, B. and Babiker, A.A. (2005). Possible immunoprotective and angionesis promoting roles for malignant cell-derived prostasomes; a new paradigm for prostatic cancer?. Advances in Experimental Medicine and Biology. 586. 107-119.
Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B. and Gros, P. (2005). Structures of complement component C3 provide insights into the function and evolution of immunity. Nature. 437 (7058). 505-511.
Johansson, H., Lukinius, A., Moberg, L., Lundgren, T., Berne, C., Foss, A., Felldin, M., Kallen, R., Salmela, K., Tibe, A., Tufveson, G., Nilsson-Ekdahl, K., Elgue, G., Korsgren, O. and Nilsson, B. (2005). Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes. 54 (6). 1755-1762.
Babiker, A.A., Nilsson, B., Ronquist, G., Carlsson, L. and Nilsson-Ekdahl, K. (2005). Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. The prostate. 62 (2). 105-114.
Nilsson-Ekdahl, K., Bengtsson, A.A., Andersson, J., Elgue, G., Rönnblom, L., Sturfelt, G. and Nilsson, B. (2004). Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. British journal of haematology. 125 (1). 74-78.
Andersson, J., Sanchez, J., Nilsson-Ekdahl, K., Elgue, G., Nilsson, B. and Larsson, R. (2003). Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated blood in vitro. Journal of biomedical materials research. 67A (2). 458-466.
Andersson, J., Nilsson-Ekdahl, K., Larsson, R., Nilsson, U.R. and Nilsson, B. (2002). C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase. Journal of immunology. 168. 5786-5791.
Moberg, L., Johansson, H., Luknius, A., Berne, C., Foss, A., Källen, R., Østraat, O., Salmela, K., Tibell, A., Tufveson, G., Elgue, G., Nilsson-Ekdahl, K., Larsson, R., Korsgren, O. and Nilsson, B. (2002). Expression and secretion of tissue factor in the islets of Langerhans: A likely explanation for the development of thrombotic reactions in clinical islet transplantation (IBMIR) in vitro. Lancet. 360. 2039-2045.
Wennberg, L., Sundberg, B., Nilsson-Ekdahl, K. and Korsgren, O. (2001). C-peptide determinations in islet xenotransplantation: A study in the pig-to-mouse model. Cell transplantation. 10. 165-173.
Jokiranta, T.S., Westin, J., Nilsson, B., Nilsson-Ekdahl, K., Hellwage, J., Gordon, D.L., Nilsson, U.R. and Meri, S. (2001). Complement C3b interactions with its ligands measured by Biacore equipment: a new powerful and informative method. International immunopharmacology. 1. 495-506.
Hong, J., Larsson, A., Nilsson-Ekdahl, K., Elgue, G., Larsson, R. and Nilsson, B. (2001). Contact between a polymer and whole blood: the sequence of events leading to thrombin generation. The journal of laboratory and clinical medicine. 138. 139-145.
Gröndahl, G., Johannisson, A., Jensen-Waern, M. and Nilsson-Ekdahl, K. (2001). Opsonization of yeast cells with equine C3 and IgG. Veterinary immunology and immunopathology. 6425. 1-15.
Nilsson-Ekdahl, K. and Nilsson, B. (1999). Phosphorylation of plasma proteins with emphasis on complement component C3. Molecular immunology. 36 (4-5). 233-240.
Hong, J., Andersson, J., Nilsson-Ekdahl, K., Elgue, G., Axén, N., Larsson, R. and Nilsson, B. (1999). Titanium is a highly thrombogenic biomaterial: Possible implications for osteogenesis. Thrombosis and haemostasis. 82. 58-64.
Nilsson, B., Hong, J., Larsson, R., Elgue, G., Nilsson-Ekdahl, K., Sahu, A. and Lambris, J.D. (1998). Compstatin inhibits complement and cellular activation in whole blood in models for extracorpereal circulation. Blood. 92. 1661-1667.
Nilsson-Ekdahl, K., Lööf, L., Ahrenstedt, Ö., Nilsson, U.R. and Nilsson, B. (1997). Defective elimination of C3b/iC3b-coatedautologous erythrocytes in patients with primary biliary cirrhosis, alcoholic cirrhosis, and ulcerative colitis. The journal of laboratory and clinical medicine. 130. 285-292.
Gong, J., Larsson, R., Nilsson-Ekdahl, K., Mollnes, T.E., Nilsson, U.R. and Nilsson, B. (1996). Chandler loops as a model for cardiopulmonary bypass circuits: Both the biomaterial and the blood- gas interaces induce complement activation in an in vitro model. Journal of clinical immunology. 16. 223-230.
Nilsson-Ekdahl, K., Michaëlsson, G., Gerdén, B., Lööf, L. and Nilsson, B. (1995). Impairments in complement receptor- and Fc receptor-mediated functions in psoriasis. Archives of dermatological research. 287. 225-230.
Nilsson-Ekdahl, K., Nilsson, B., Gölander, C.G., Elwing, H., Lassen, B. and Nilsson, U.R. (1993). Complement activation on radio frequency plasma modified polystyrene surfaces. Journal of colloid and interface science. 158. 121-128.
Pekna, M., Nilsson, L., Nilsson-Ekdahl, K., Nilsson, U.R. and Nilsson, B. (1993). Evidence for iC3 generation during cardiopulmonary bypass as the result of blood-gas interaction. Clinical and experimental immunology. 91. 404-409.
Nilsson, U.R., Larm, O., Storm, K.E., Nilsson, B., Elwing, H. and Nilsson-Ekdahl, K. (1993). Modification of the complement binding properties of polystyrene: Effects of end-point heparin attachment. Scandinavian journal of immunology. 37. 349-354.
Nilsson, B., Grossberger, D., Nilsson-Ekdahl, K., Riegert, P., Becherer, J.D. and Nilsson, U.R. (1992). Conformational differences between surface-bound and fluid-phase C3. Epitope mapping by cDNA expression. Biochemical journal. 282. 715-721.
Nilsson, B., Nilsson-Ekdahl, K., Sjöholm, A., Nilsson, U.R. and Sturfelt, G. (1992). Detection and characterization of immunoconglutinins in patients with systemic lupus erythematosus (SLE): serial analysis in relation to disease course. Clinical and experimental immunology. 90. 251-255.
Nilsson-Ekdahl, K., Pekna, M., Nilsson, B. and Nilsson, U.R. (1992). Generation of iC3 on the interphase between blood and gas. Scandinavian journal of immunology. 35. 85-91.
Gölander, C.G., Lassen, B., Nilsson-Ekdahl, K. and Nilsson, U.R. (1992). RF-plasma-modified polystyrene surfaces for studying complement activation. Journal of biomaterials science. Polymer edition. 4. 25-30.
Nilsson-Ekdahl, K., Nilsson, B., Storm, K.E. and Nilsson, U.R. (1992). Techniques to study functional properties of IgG preparations for parenteral use. Life science advances. 11. 221-227.
Nilsson-Ekdahl, K., Lööf, L., Nyberg, A., Nilsson, U.R. and Nilsson, B. (1991). Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis. Gastroenterology. 101. 1076-1082.
Alston-Smith, J., Ljungqvist, O., Ware, J. and Nilsson-Ekdahl, K. (1991). Regulation of rat hepatocyte fructose 1,6-diphosphatase activity during endotoxemia. Surgical research communications. 11. 67-75.
Kuraya, M., Nilsson, B., Nilsson-Ekdahl, K. and Klein, E. (1990). C3d-mediated negative and positive signals on the proliferation of human B cells separated from blood. Immunology letters. 26. 51-58.
Nilsson, B., Nilsson-Ekdahl, K., Avila, D., Nilsson, U.R. and Lambris, J.D. (1990). Neoantigens in C3 as detected by monoclonal antibodies: Mapping of the recognized epitopes by synthetic peptides. Biochemical journal. 268. 55-61.
Nilsson, B., Nilsson-Ekdahl, K., Svarvare, M., Bjelle, A. and Nilsson, U.R. (1990). Purification and characterization of IgG immunoconglutinins from patients with SLE: Implications for a regulatory function. Clinical and experimental immunology. 82. 262-267.
Ramos, O.F., Nilsson, B., Nilsson-Ekdahl, K., Eggertsen, G., Yefenov, E. and Klein, E. (1989). Elevated NK-mediated lysis of Raji and Daudi cells carrying fixed iC3b fragments. Cellular immunology. 119. 459-469.
Ahrenstedt, Ö., Knutson, L., Nilsson, B., Nilsson-Ekdahl, K., Odlind, B. and Hällgren, R. (1989). Enhanced local production of the complement components in the small intestine in Crohn's disease. The New England journal of medicine. 322. 1345-1349.
Boija, P.O., Nilsson-Ekdahl, K., Nylander, G. and Ware, J. (1987). Hemorrhagic hypotension and hepatic cell pyruvate kinase and fructose-1,6-diphosphatase activity in vivo. Surgical research communications. 2. 119-124.
Nilsson-Ekdahl, K. and Ekman, P. (1985). Fructose-1,6-bisphosphatase from rat liver. A. Journal of biological chemistry. 260. 14173-14179.

Review

Babiker, A.A., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2010). Prostasome Involvement in the Development and of Prostate Cancer. Open prostate cancer journal. in press.
Rönnelid, J., Åhlin, E., Nilsson, B., Nilsson-Ekdahl, K. and Mathsson, L. (2008). Immune complex mediated cytokine production is regulated by classical pathway complement activation both in vivo and in vitro. Advances in experimental medicine and biology. 632. 187-201.

Chapter in Book

Nilsson, B. and Nilsson-Ekdahl, K. (1988). Components of the alternative pathway. Springer Verlag. In: Rother & Hänsch (eds.) The complement system. 23-49.

Ph.D. Thesis

Nilsson-Ekdahl, K. (1987). Studies on the regulation of rat liver pyruvate kinase and fructose 1,6-bisphosphatase. Doctoral Thesis. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the faculty of Medicine 104. 41 pp.

Conference paper (peer-reviewed)

Patent

Nilsson, B., Andersson, J., Neff, J., Caldwell, K. and Nilsson-Ekdahl, K. (2005). Elutable Surface coatings.
Nilsson-Ekdahl, K., Nilsson, B., Andersson, J., Neff, J. and Caldwell, K. (2004). Surface coating comprising bioactive compound.

Works in Popular Science

Nilsson-Ekdahl, K. (2001). Magisterprogrammet i biomedicin. Klinisk kemi. 1. 34-35.
Nilsson-Ekdahl, K. (2000). Biomedicinsk kemi. Klinisk kemi. 5. 151-152.

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