Kristina Nilsson-Ekdahl

Professor

Employment	Professor

School of Natural Sciences

Visit Address	Norra vägen 49,39234
Postal Address	Norrgård, SE-39182 Kalmar
Email	kristina.nilsson-ekdahl@hik.se
Office Phone	0480-446269
Cell Phone	072-2320726
Fax	0480-446262

Subject List

Subject	Subject Area
Immunology	Biomedical Sciences

Project List

Title	Subject	Started	Ended
Biocompatibility of Blood-Contacting Surfaces – Lessons Lear	Immunology	2005	2010
Polymorphisms in innate immunity genes	Biomedical Sciences	2005	2010

Publication List

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Journal paper (peer-reviewed)

Bäck, J., Sanchez, J., Elgue, G., Nilsson-Ekdahl, K. and Nilsson, B. (2010). Activated platelets induce FXII-mediated contact activation. Biochem Biophys Res Commun. 391. 11-17.

Nilsson-Ekdahl, K., Nilsson, B., Lambris, J. and Nilsson, P. (2010). Activation and binding of complement proteins to activated platelets is not the result of proteolytic activation of complement components. Journal of Immunology. in press.

Nilsson, B., Korsgren, O., Lambris, J. and Nilsson-Ekdahl, K. (2010). Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition. Trends in Immunology. 31. 32-38.

Nilsson, P., Engberg, A., Bäck, J., Faxälv, L., Lindahl, T., Nilsson, B. and Nilsson-Ekdahl, K. (2010). Immobilization of apyrase creates and antithrombotic biomaterial surface. Biomaterials. in press.

Babiker, A.A., Magnusson, P.U., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2010). Pro- and Antiangiogenic Factors in Prostasomes of Normal and Malignant Cell Origin.. The Prostate. in press.

Mangsbo, S., Sanchez, J., Anger, K., Lambris, J., Loskog, A., Nilsson-Ekdahl, K., Nilsson, B. and Tötterman, T. (2009). Complement activation by CpG 2006 in a human whole blood loop system; potential mechanisms and ensuing immune related effects. Journal of Immunology. 183. 6724-6731.

Engberg, A., Sandholm, K., Mollnes, T.E., Hong, J. and Nilsson-Ekdahl, K. (2009). Hirudin versus heparin blood for use in whole blood in vitro biocompatibility models. J Biomed Mat Res A. 89A. 951-959.

Lundgren, B.A., Rorsman, F., Portela-Gomes, G., Grimelius, L., Nilsson-Ekdahl, K., Nilsson, B. and Ekwall, O. (2009). Identification of complement C3 as an autoantigen in inflammatory bowel disease. Journal of Gastroenterology and Hepatology. Oct 13. [Epub ahead of print].

Engberg, A., Sandholm, K., Persson, J., Nilsson, B., Lindahl, G. and Nilsson-Ekdahl, K. (2009). Inhibition of complement activation on a model biomaterial by Streptococcal M-protein derived peptides. Biomaterials. 30. 2653-2659.

Tsai, J.A., Lund, M., Lundell, L. and Nilsson-Ekdahl, K. (2009). One-lung ventilation during thoracoabdominal esophagectomy elicits complememnt activation. Journal of Surgical Research. 152. 331-337.

Bäck, J., Huber-Lang, M., Sanchez, J., Nilsson-Ekdahl, K. and Nilsson, B. (2009). Regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and artificial surfaces.. Biomaterials. 30. 6573-80.

Nilsson-Ekdahl, K., Blomberg, C., Henningsson Johnsson, A., Dahle, C., Håkansson, I., Sandholm, K. and Ernerudh, J. (2009). Systemic and Intrathecal Complement Activation in Multiple Sclerosis and Guillan-Barré Syndrome. Molecular Immunology. 46. 2848.

Tjernberg, J., Nilsson-Ekdahl, K., Korsgren, O. and Nilsson, B. (2008). Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation. 85. 1193-1199.

Hamad, O.A., Nilsson-Ekdahl, K., Nilsson, P., Andersson, J., Magotti, P., Lambris, J.D. and Nilsson, B. (2008). Complement activation triggered by chondroitin sulfate reelased by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis. 6. 1413-1421.

Goto, M., Tjernberg, J., Dufrane, D., Elgue, G., Brandhorst, D., Nilsson-Ekdahl, K., Brandhorst, H., Wennberg, L., Kurokawa, Y., Satomi, S., Gianello, P., Korsgren, O. and Nilsson, B. (2008). Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation. 15. 225-234.

Andersson, P.O., Chen, H., Nilsson, B. and Nilsson-Ekdahl, K. (2008). The Tick-Over Theory Revisited: Formation and Regulation of the Soluble Alternative Complement C3 Convertase (C3(H2O)Bb). Molecular Immunology. 45. 2370-2379.

Nilsson-Ekdahl, K., Norberg, D., Sturfelt, G., Nilsson, U.R. and Nilsson, B. (2007). A rapid, inexpensive, and easy-to-perform haemolytic complement assay using serum of buffer-changed EDTA-plasma: Its use for differential diagnosis and follow-up of patients with systemic lupus erythematosus. Clin Dignostic Lab Immunol. 14. 549-555.

Markiewski, M., Nilsson, B., Nilsson-Ekdahl, K., Mollnes, T.E. and Lambris, J.D. (2007). Complement and Coagulation: Strangers or Partners in Crime?. Trends in Immunology. 28(4). 184-192.

Nilsson-Ekdahl, K., Henningsson, A.J., Sandholm, K., Forsberg, P., Ernerudh, J. and Ekerfelt, C. (2007). Immunity in borreliosis with special emphasis on the role of complement. Advances in Experimental Medicine and Biology. 598. 198-213.

Babiker, A.A., Hamad, O.A., Sanchez, J., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2007). Prothrombotic Effect of Prostasomes of Metastatic Cell and Seminal Origin. The Prostate. 67. 378-388.

Babiker, A.A., Nilsson-Ekdahl, K., Nilsson, B. and Ronquist, G. (2007). Prothrombotic Effects of Prostasomes Isolated from Prostatic Cell Lines and Seminal Plasma. Seminars in Thrombosis and Hemostasis. 33. 80-86.

Henningsson, A.J., Ernerudh, J., Sandholm, K., Carlsson, S., Granlund, H., Jansson, C., Nyman, D., Forsberg, P. and Nilsson-Ekdahl, K. (2007). Raised Intrathecal Levels of Complement Components C1q and C3a in Acute Neuroborreliosis. J Neuroimmunol. 183(1-2). 200-207.

Norda, R., Knutson, F., Berseus, O., Åkerblom, O., Nilsson-Ekdahl, K., Stegmayr, B. and Nilsson, B. (2007). Unexpected effects of donor gender on the storage of liquid plasma. Vox sang. 93. 223-228.

Larsson, R., Andersson, P.O. and Nilsson-Ekdahl, K. (2006). A novel application of multi-wavelength TIRF spectroscopy for real time monitoring of antithrombin interactions with immobilized heparin. Biosensors & bioelectronics. 21 (10). 1973-1980.

Andersson, J., Nilsson, B. and Nilsson-Ekdahl, K. (2006). Functionalized Pluronic˙ as a linker for immobilization of bioactive molecules on a material surface - a new strategy towards improved biomaterial-blood compatibility. Journal of biomedical materials research. 76A (1). 25-34.

Babiker, A.A., Ronquist, G., Nilsson, B. and Nilsson-Ekdahl, K. (2006). Overexpression of ecto-protein kinases in prostasomes of metastatic origin. Prostate. 66 (7). 675-686.

Nilsson-Ekdahl, K., Ronquist, G., Nilsson, B. and Babiker, A.A. (2006). Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: A new paradigm for prostatic cancer?. Advances in experimental medicine and biology. 586. 107-119.

Nilsson, B., Nilsson-Ekdahl, K., Mollnes, T.E. and Lambris, J.D. (2006). The role of complement in biomaterial-induced inflammation. Molecular immunology. 44 (1-3). 82-94.

Andersson, J., Nilsson-Ekdahl, K., Lambris, J.D. and Nilsson, B. (2005). Complement activation on a model biomaterial surface: Binding of C3b via the alternative amplification loop to plasma proteins adsorbed to the surface. Biomaterials. 26 (13). 1477-1485.

Hong, J., Azens, A., Nilsson-Ekdahl, K., Granqvist, C.G. and Nilsson, B. (2005). Contact between various metal surfaces and whole blood causes material-specific thrombin generation. Biomaterials. 26 (12). 1397-1403.

Mathsson, L., Tejde, A., Carlson, K., Höglund, M., Nilsson, B., Nilsson-Ekdahl, K. and Rönnelid, J. (2005). Cryoglobulin-induced cytokine production via Fc-gamma-RIIa: inverse effects of complement blockade on the production of TNF-alfa and IL-10. Implications for the growth of malignant B-cell clones. British journal of haematology. 129 (6). 830-838.

Nilsson-Ekdahl, K., Ronquist, G., Nilsson, B. and Babiker, A.A. (2005). Possible immunoprotective and angionesis promoting roles for malignant cell-derived prostasomes; a new paradigm for prostatic cancer?. Advances in Experimental Medicine and Biology. 586. 107-119.

Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B. and Gros, P. (2005). Structures of complement component C3 provide insights into the function and evolution of immunity. Nature. 437 (7058). 505-511.

Johansson, H., Lukinius, A., Moberg, L., Lundgren, T., Berne, C., Foss, A., Felldin, M., Kallen, R., Salmela, K., Tibe, A., Tufveson, G., Nilsson-Ekdahl, K., Elgue, G., Korsgren, O. and Nilsson, B. (2005). Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes. 54 (6). 1755-1762.

Babiker, A.A., Nilsson, B., Ronquist, G., Carlsson, L. and Nilsson-Ekdahl, K. (2005). Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. The prostate. 62 (2). 105-114.

Tejde, A., Mathsson, L., Nilsson-Ekdahl, K., Nilsson, B. and Rönnelid, J. (2004). Immune complex stimulation of peripheral blood mononuclear cells result in enhancement or suppression of IL-12 production dependent on access to a functionally active complement system. Clinical and experimental immunology. 137 (3). 521-528.

Nilsson-Ekdahl, K., Bengtsson, A.A., Andersson, J., Elgue, G., Rönnblom, L., Sturfelt, G. and Nilsson, B. (2004). Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. British journal of haematology. 125 (1). 74-78.

Rönnelid, J., Mathsson, L., Tejde, A., Nilsson-Ekdahl, K. and Nilsson, B. (2003). Immune complexes from SLE sera induce IL-10 production by a Fc-RII-dependent mechanism: A possible vicious circle maintaining B cell hyperactivity in SLE. Annals of the rheumatic diseases. 62. 37-42.

Andersson, J., Sanchez, J., Nilsson-Ekdahl, K., Elgue, G., Nilsson, B. and Larsson, R. (2003). Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated blood in vitro. Journal of biomedical materials research. 67A (2). 458-466.

Andersson, J., Nilsson-Ekdahl, K., Larsson, R., Nilsson, U.R. and Nilsson, B. (2002). C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase. Journal of immunology. 168. 5786-5791.

Moberg, L., Johansson, H., Luknius, A., Berne, C., Foss, A., Källen, R., Østraat, O., Salmela, K., Tibell, A., Tufveson, G., Elgue, G., Nilsson-Ekdahl, K., Larsson, R., Korsgren, O. and Nilsson, B. (2002). Expression and secretion of tissue factor in the islets of Langerhans: A likely explanation for the development of thrombotic reactions in clinical islet transplantation (IBMIR) in vitro. Lancet. 360. 2039-2045.

Özmen, L., Nilsson-Ekdahl, K., Elgue, G., Larsson, R., Korsgren, O. and Nilsson, B. (2002). Inhibition of thrombin with Melagatran abrogates instant blood mediated islet reaction (IBMIR) in vitro: Possible application in clinical allogeneic pacreatic islet transplantation. Diabetes. 51. 1779-1784.

Andersson, J., Larsson, R., Richter, R., Nilsson-Ekdahl, K. and Nilsson, B. (2001). Binding of a model regulator of complement activation (RCA) to a biomaterial surface: Surface-bound factor H inhibits complement activation. Biomaterials. 22 (17). 2435-2443.

Wennberg, L., Sundberg, B., Nilsson-Ekdahl, K. and Korsgren, O. (2001). C-peptide determinations in islet xenotransplantation: A study in the pig-to-mouse model. Cell transplantation. 10. 165-173.

Jokiranta, T.S., Westin, J., Nilsson, B., Nilsson-Ekdahl, K., Hellwage, J., Gordon, D.L., Nilsson, U.R. and Meri, S. (2001). Complement C3b interactions with its ligands measured by Biacore equipment: a new powerful and informative method. International immunopharmacology. 1. 495-506.

Hong, J., Larsson, A., Nilsson-Ekdahl, K., Elgue, G., Larsson, R. and Nilsson, B. (2001). Contact between a polymer and whole blood: the sequence of events leading to thrombin generation. The journal of laboratory and clinical medicine. 138. 139-145.

Nilsson-Ekdahl, K. and Nilsson, B. (2001). Increased affinity between CR1 and C3b phosphorylated by a casein kinase released by activated human platelets. European journal of immunology. 31. 1047-1054.

Gröndahl, G., Johannisson, A., Jensen-Waern, M. and Nilsson-Ekdahl, K. (2001). Opsonization of yeast cells with equine C3 and IgG. Veterinary immunology and immunopathology. 6425. 1-15.

Hong, J., Nilsson-Ekdahl, K., Reynolds, H., Larsson, R. and Nilsson, B. (1999). A new in vitro model to study interaction between whole blood and biomaterials. Studies of platelet and coagulation activation and the effect of aspirin. Biomaterials. 20. 603-611.

Nilsson-Ekdahl, K., Elgue, G. and Nilsson, B. (1999). Phosphorylation of coagulation factor XI by a casein kinase released by activated human platelets increases its susceptibility to activation by factor XIIa and thrombin. Thrombosis and haemostasis. 82. 1283-1289.

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